(Tuesday, 1 may HealthDay News) - moderate weight loss reduces the level of inflammation that have been linked to certain cancers, at least in postmenopausal women, a new study suggests.
According to the results, older women who have lost at least 5% of their body weight by diet alone or diet and exercise has shown a significant reduction of the markers key blood inflammatory such as the C - reactive protein and Interleukin-6.
In addition to risk of heart disease, high levels of these markers were also associated with an increased risk of several cancers, including cancer of the breast, colon, lung and endometrial cancer.
Results appear on 1 may in the journal Cancer Research.
"Our results support the weight loss through calorie reduction and exercise increased as a means of reducing inflammatory biomarkers and thus potentially reduce the risk of cancer in overweight and anti-obesity postmenopausal women," said researchers led by Dr. Anne McTiernan, Director of the Centre for prevention at the Fred Hutchinson Cancer Research Center in Seattle.
The goal of losing 10% of their body weight, women have been placed on a restricted calorie diet, was asked to participate in a vigorous aerobic exercise moderate - to 45 minutes a day five days per week, or told to do both.
In the study of one year, rate of C - reactive protein fell 36% in the diet only group and 42% in the Group of diet and exercise. A decreased 23% in the Group of the diet and 24% in the Group of diet and exercise, the study showed levels of Interleukin-6. There are reductions of these levels observed in women who have lost at least 5% of their body weight. One exercise does not affect levels of markers of inflammation.
No there was no information which, if any, women in the 438 study developed cancer. ""But a reduction of 40% of protein C - reactive"would reduce the breast, endometrial and the other the risk of cancer in postmenopausal women," said the authors of the study.
Dr. Louis Aronne, founder and Director of the program of full weight to New York-Presbyterian Hospital/Weill Cornell Medical Center, in New York, said: "this adds to the whole of the evidence showing that with a loss of weight, retraction of fat cells and hormones inflammatory go down.". There are many things outside the coronary artery disease that depend on inflammation. »
Dr. Mitchell Roslin, Chief of surgery of obesity to the Lenox Hill Hospital, in New York, agreed. "Obesity induced a chronic state of inflammation which may also be the cause of metabolic diseases such as type 2 diabetes and some cancers," he said. "Obesity is the engine of this inflammatory State, and when we reverse it, we also reverse the process which causes cancers and diabetes."
More information
Discover the benefits of weight loss moderate to the U.S. Centers for Disease Control and Prevention.
SOURCES: Louis Aronne, M.D., founder and Director, comprehensive weight Control program, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York City; Mitchell Roslin, M.D., Chief of surgery of obesity, Lenox Hill Hospital, New York City; 1 May 2012, Cancer Research
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