(Monday, 30 April HealthDay News) - A new analysis that can help women in their forties in interpreting mammography guidelines said those with a family history of breast cancer or breast tissue is extremely dense should start regular projections.
The advantages of doing a mammogram every two years outweigh the risks for these women in particular, who are at an increased risk of developing breast cancer, according to a study from U.S. National Cancer Institute-funded.
"Among a group of women who have twice the average level of risk, screening every two years from 40 years has the same balance of benefits and harms as starting at the age of 50," said researcher Dr. Jeanne Mandelblatt, Deputy Director for science of the population of Georgetown Lombardi Comprehensive Cancer Center in Washington, D.c.D.C.
The research is published in the Annals of Internal Medicine - may 1.
Currently, experts do not agree on the frequency of projections and the intervals between them. In 2009, the debate of the U.S. Preventive Services Task Force turned on when it recommends that Screening Mammograms every two years for women aged 50 to 74. He advises women in their forties at average risk of breast cancer to discuss the advantages and disadvantages with their doctors and then decide on the value of screening. Other organizations, including the American Cancer Society, will continue to inform women 40 and beaver to get each year of screening mammography.
The Working Group made the recommendations after it concluded that mammograms every two years in average-risk women in their forties pose considerable harm, such as false-positive results leading to unnecessary invasive procedures or causing anxiety.
For this study, Mandelblatt and his colleagues developed to identify factors that increase the risk of cancer for women aged 40 to 49. To do this, they evaluated 66 articles published and the Breast Cancer Surveillance Consortium cancer Institute data.
13 Risk factors, they found the breast tissue is extremely dense or a parent first degree with cancer of the breast (parent, brother or child) doubles the risk of breast cancer in women aged 40 to 49. Breast density is determined by mammography.
About 13% of women in their forties have breast tissue is extremely dense and 9% have a parent first degree with breast cancer.
Then, they performed a technique called collaborative modeling to estimate the harms and benefits of mammography every-other-year for these under-50 women at high risk.
Researchers gathered four independent patterns to see if a doubling of risk changed the balance of harms and benefits.
The four models found that high-risk women 40 to 49 who begin every-other-year projections at the age of 40 years the same benefit-harm risk report average women 50 to 74, of mammograms every two years.
"Our models say that they [women] can do", said Mandelblatt. The findings will help inform women and professional organizations that make recommendations, the experts said.
The researchers found small differences in benefits between Mammography film and digital mammography more recent. Digital forms were more false positives.
In digital mammography, the breast image is electronic and stored in the computer rather than on film.
New research confirms some of what experts know already, said Judith Malmgren, affiliate professor of epidemiology at the University of Washington, in Seattle. "We already knew that women with a family history of breast cancer should begin screening at the age of 40 years", she says.
The new data "show more conclusive balance [of harms and benefits]," said.
However, modeling studies are not real, so they have limits, she said.
The model took into account life years gained and night avoided, as well as potential of breast cancer deaths, she said. "The model does not take account that the earlier the detection stage requires treatment," she said.
In an editorial accompanying the research, Dr. Otis Brawley, the American Cancer Society wrote that screening based on the risk - zero those at higher risk, can focus on more likely to benefit women.
He predicted the future, that will focus more on risk-based testing. "Ultimately, the preferences of women, recognizing the potential for harm and benefits, must be respected," he said.
More information
The American Cancer Society has more about mammograms.
SOURCES: Dr. Jeanne s. Mandelblatt, M.P.H., Director Deputy for Science population, Georgetown University Lombardi Comprehensive Cancer Center, Washington, D.C., affiliate Judith Malmgren, PhD, Assistant Professor of epidemiology, University of Washington School of Public Health, Seattle; 1 May 2012, Annals of Internal Medicine
Copyright © 2012 HealthDay. All rights reserved.
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